Whenever you submit a route, it goes through an approval process. First, it is checked by software itself (i.e. to see if airways are valid), then it goes through manual check by moderator. The most common reason for rejections during moderation is not using airways and listing all fixes one by one.

Example:

• bad: EAONE AHN GLOVR LIB SAMMB FOZZY ZITTO HPW HUBBS PXT GARED RIDGY ENO SKIPY BESSI EDJER DAVYS HOLEY BRAND KORRY RBV TYKES MINKS RENUE APPLE PROUD
• good: UGAAA2 AHN J208 HPW J191 PXT KORRY3

If you get too many routes rejected, vroute will stop accepting new routes from you automatically and the "New route" tab will disappear. If you're unsure why a certain route does not get accepted, please post your question on vroute's support forum.